Table 4.
Effect of transferrin saturation concentration GWAS identified variants on breast cancer
| SNPs | Chr: BP (Build 37) | Locus | Effect/other allele | Transferrin saturation (μmol/L) | Overall breast cancer | ER-positive breast cancer | ER-negative breast cancer | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Betab (SE) | P value | Betac (SE) | P value | Betac (SE) | P value | Betac (SE) | P value | ||||
| rs8177240 | 3: 133,477,701 | TF | T/G | 0.100 (0.008) | 7.24E−38 | −0.014 (0.007) | 0.039 | −0.014 (0.008) | 0.072 | −0.012 (0.012) | 0.304 |
| rs1800562a | 6: 26,093,141 | HFE | A/G | 0.577 (0.016) | 2.19E−270 | −0.003 (0.014) | 0.831 | 0.010 (0.016) | 0.535 | −0.027 (0.025) | 0.288 |
| rs1799945a | 6: 26,091,179 | HFE | C/G | −0.231 (0.010) | 5.13E−109 | −0.001 (0.009) | 0.913 | −0.003 (0.011) | 0.804 | −0.014 (0.016) | 0.380 |
| rs7385804 | 7: 100,235,970 | TFR2 | A/C | 0.054 (0.008) | 6.07E−12 | 0.016 (0.007) | 0.015 | 0.010 (0.008) | 0.225 | 0.017 (0.012) | 0.151 |
| rs855791a | 22: 37,462,936 | TMPRSS6 | A/G | −0.190 (0.008) | 6.41E−137 | −0.003 (0.006) | 0.627 | 0.001 (0.008) | 0.852 | −0.013 (0.012) | 0.255 |
a3 SNPs used in the conservative analyses. GWAS genome-wide association studies, SNPs single nucleotide polymorphisms, Chr chromosome, BP base pair, SE standard error, ER oestrogen receptor
bBeta units are per-allele effect estimates in saturation concentration concentrations
cPer-allele logarithm of the odds ratios between breast cancer cases and controls