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. 2021 Jul 6;15:336. doi: 10.1186/s13256-021-02934-y

Table 1.

Summary of cases with ECMO of myocarditis from immune checkpoint inhibitors.

Authors, year Age, sex Malignancy ICI Doses prior to myocarditis Treatments utilized Outcome
Arangalage et al. (2017) 35, F Melanoma

Ipi 3 mg/kg,

Nivo 1 mg/kg

1 Intravenous solumedrol 1 g/day and IVIG followed by ECMO and plasma exchange followed by tacrolimus Survived
Frigeri et al. (2018) 76, F

Metastatic

lung adenocarcinoma

Nivo

(dose NA)

7

ECMO, IABP, intravenous methylprednisolone 5 mg/kg/day, plasmapheresis, infliximab

5 mg/kg, three doses

Survived
Yamaguchi et al. (2018) 60, M Melanoma

Nivo

2 mg/kg

13 ECMO, IABP, intravenous prednisolone 1000 mg/day for 3 days + IVIG at 50 g/day for 2 days Survived
Imai et al. (2018) 70, M Squamous cell carcinoma of lung

Pembro

(200 mg)

2 Intravenous methylprednisolone (1 g/day) for 3 days, IVIG 1 g/kg for 2 days, ECMO, IABP Died

ECMO extracorporeal membrane oxygenation, ICI immune checkpoint inhibitors, IABP intraaortic balloon pump, IVIG intravenous immunoglobulin, ipi ipilimumab, nivo nivolumab, pembro pembrolizumab, mg/kg milligrams/kilogram body weight, NA not available