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. 2021 Jul 5;2:73. doi: 10.1186/s43058-021-00177-y

Table 5.

Intervention cost per outcome

Publication Continuum of care costed Total implementation cost Cost per client
Intervention Control Intervention Control
HIVST

Choko et al. 2019 [97]

Intervention: HIVSTa

Control: SOC

Testing and initiated ART treatment

Total intervention cost (excluding ART or VMMC):

1. STb = USD 3446.03

2. ST + $3 = USD 3678.44

3. ST + $10 = USD 7469.87

4. ST + lottery = USD 1175.64

5. ST + phone = USD 3 464.41

SOC = USD 557.40

1. Cost per male partner tested + attended male friendly clinics (MFC):

a. ST = USD 40.54

b. ST + $3 = USD 23.73

c. ST + $10 = USD 28.08

d. ST + lottery = USD 39.19

e. ST + phone = USD 41.24

2. Cost per male partner tested + ARTc/VMMCd:

a. ST = USD 127.63

b. ST + $3 = USD 94.32

c. ST + $10 = USD 109.85

d. ST + lottery = USD 167.95

e. ST + phone = USD 157.47

1. Cost per male partner tested + attended MFCe: SOCf = USD 9.95

2. Cost per male partner tested + ART/VMMC: SOC = USD 39.81

George et al. 2018 [98]

Intervention: HIVST

Controls: SOC and Enhanced SOC

Testing

Total intervention cost

• Trucker = USD 3678.44

• FSWg = USD 7469.87

1. Total cost per intervention (Trucker):

a. HIVST = USD 544.03

2. Total cost per intervention (FSW):

• HIVST = USD 925.55

1. Total intervention cost

• SOC = USD 284.81

• Enhanced SOC = USD 335.69

2. Total cost per intervention (FSW):

• SOC = USD 411.18

• Enhanced SOC = USD 473.04

1. Cost per client (Trucker):

• HIVST = USD 20.92

2. Cost per client (FSW):

• HIVST = USD 11.43

3. Cost per additional client tested (Trucker):

• HIVST = USD 21.48

4. Cost per additional client tested (FSW):

• HIVST = USD 15.80

1. Cost per client (Trucker):

• SOC = USD 28.48

• Enhanced SOC = USD 33.57

2. Cost per client (FSW):

• SOC = USD 9.56

• Enhanced SOC = USD 10.28

3. Cost per additional client tested (Trucker):

• SOC = USD 26.26

• Enhanced SOC = USD 30.80

4. Cost per additional client tested (FSW):

• SOC = USD 9.90

• Enhanced SOC = USD 10.63

Maheswaran et al. 2016 [99]

Intervention: HIVST

Control: FBHTCh

Testing, HIV diagnosis, and ART initiation Total annual health provider cost: HIVST = USD 133 300

• Ndirande = USD 50 899

• Chilomani = USD 56 760

• QECHl = USD 84 436

1. Direct cost per individual tested: HIVST = USD 8.78

2. Direct cost per HIV positive identified: HIVST = USD 97.50

3. Direct cost per HIV positive individuals assessed for ART eligibility: HIVT Service = USD 165.14

4. Direct cost per HIV positive individuals initiated onto ART:

• HIVST = USD 319.67

1. Direct cost per individual tested:

• Ndirande = USD 7.53

• Chilomani = USD 10.57

• QECH = USD 8.90

2. Direct cost per HIV positive identified:

• Ndirande = USD 67.33

• Chilomani = USD 76.39

• QECH = USD 28.30

3. Direct cost per HIV positive individuals assessed for ART eligibility:

• Ndirande = USD 83.48

• Chilomani = USD 92.38

• QECH = USD 37.73

4. Direct cost per HIV positive individuals initiated onto ART:

• Ndirande = USD 109.85

• Chilomani = USD 132.42

QECH = USD 85.75

Home-based HIV counseling and testing

Bogart et al. 2017 [95]

Intervention: HBHTCj

Control: EBHTCk

Testing HBHTC = USD 62 247 EBHTC = USD 25 780 HBHTC = USD 45.09 EBHTC = USD 46.99

Cham et al. 20191 [96]

Intervention: HBHTC

Controls: PITCl and VBHTCm

Testing and HIV diagnosis

1. Total intervention cost = USD 720 607.67

2. Total cost per intervention: HBHTC = USD 176 865.66

1. Cost per intervention

• PITC = USD 404 364.89

• VBHTC = USD 139 377.12

1. Cost per test: HBHTC = USD 6.45

2. Cost per new HIV diagnosed: HBHTC = USD 354.44

1. Cost per test:

• PITC = USD 4.55

• VBHTC = USD 7.98

2. Cost per new HIV diagnosed:

• PITC = USD 123.66

• VBHTC = USD 372.67

Mulogo et al., 20132 [101]

Intervention: HBHTC

Control: FBHTC

Testing and HIV diagnosis. USD 3114 USD 2462

1. Cost per client tested: USD 5.0

2. Average cost per client diagnosed HIV positive: USD 1

1. Cost per client tested: USD 6.4

2. Average cost per client diagnosed HIV positive: USD 2

Tabana et al. 20153 [104]

Intervention: HBHTC

Control: FBHTC

Testing USD 233 239.02 USD 146 615.12 USD 29 USD 38
Mobile HIV Counseling and Testing

Meehan et al. 2017 [100]

Intervention: MHTCn

Control: SAHTSo

Testing, HIV diagnosis, referral to treatment. USD 77 764 USD 96 616

1. Cost per person counseled: USD 25

2. Cost per person test: USD 25

3. Cost per HIV diagnosed: USD 1051

4. Cost per HIV referred: USD 1065

5. Cost per linked to HIV care: USD 2102

1. Cost per person counseled: USD 50

2. Cost per person test: USD 51

3. Cost per HIV diagnosed: USD 755

4. Cost per HIV referred: USD 773

5. Cost per linked to HIV care: USD 1039

Parker et al. 2015 [103]

Intervention: MHTC

Control: HBHTC

Testing and HIV diagnosis.

1. Cost per person reached: USD 24

2. Cost per HIV positive identified: USD 543

3. Cost per HIV positive identified and linked to care: USD 1698

4. Cost per person reached: USD 11

5. Cost per HIV positive identified: USD 343

6. Cost per HIV positive identified and linked to care: USD 797

Provider-initiated counseling and testing

Obure et al. 2012 [102]

Intervention: PITC

Control: VCTp

Testing and HIV diagnosis.

Average annual economic cost

1. Kenya: USD 3 721

2. Swaziland: USD 10 407

Average annual economic cost

1. Kenya: USD 11 969

2. Swaziland: USD 16 716

1. Average cost per client:

• Kenya: USD 5.71

• Swaziland: USD 7.79

2. Average cost per client diagnosed HIV positive:

• Kenya: USD 46.96

• Swaziland: USD 47.85

1. Average cost per client:

• Kenya: USD 8.27

• Swaziland: USD 9.44

2. Average cost per client diagnosed HIV positive:

• Kenya: USD 110.32

• Swaziland: USD 45.56

Estimated incremental cost over 2.5 years;

2ICER = 3.50

3ICER = 19

aHIVST: HIV self-testing

bST standard of care + access to HIVST

cART antiretroviral therapy

dVMMC voluntary medical male circumcision

eMFC male friendly clinics

fSOC standard of care

gFSW female sex workers

hFBHTC facility-based HIV testing and counseling

iQECH Queen Elizabeth Central Hospital

jHBHTC home-based HIV testing and counseling

kEBHTC event-based HIV testing and counseling

lPITC provider-initiated testing and counseling

mVBHTC venue-based HIV testing and counseling

nMHTC mobile-based HIV testing and counseling

oSAHTS stand-alone community-based HIV testing and counseling

pVCT voluntary counseling and testing