TABLE 3.
Association of CRP (ln) with adverse outcomes
| MINOCA | MI‐CAD | ||||||
|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | p value | n | HR (95% CI) | p value | p int. | |
| Model 1 | |||||||
| All‐cause mortality | 9709 | 1.22 (1.17–1.26) | <.001 | 96 221 | 1.22 (1.21–1.23) | <.001 | 0.904 |
| MACE | 9469 | 1.08 (1.04–1.12) | <.001 | 93 813 | 1.17 (1.16–1.18) | <.001 | <.001 |
| Model 2 | |||||||
| All‐cause mortality | 7971 | 1.21 (1.16–1.26) | <.001 | 81 353 | 1.18 (1.16–1.19) | <.001 | 0.329 |
| MACE | 7761 | 1.09 (1.04–1.13) | <.001 | 79 116 | 1.12 (1.11–1.13) | <.001 | .019 |
| Model 3 | |||||||
| All‐cause mortality | 4095 | 1.23 (1.15–1.32) | <.001 | 42 971 | 1.24 (1.21–1.26) | <.001 | 0.764 |
| MACE | 3926 | 1.09 (1.02–1.16) | .013 | 41 142 | 1.18 (1.16–1.20) | <.001 | .021 |
Abbreviations: CI, confidence interval; HR, hazard ratio; MACE, major adverse cardiovascular event.
Note: Model 1: adjusted for sex, age, current smoking, hypertension, diabetes, hyperlipidemia, estimated glomerular filtration rate, previous heart failure, previous stroke, peripheral vascular disease, chronic obstructive pulmonary disease, dementia, previous or present cancer, ST‐segment changes, atrial fibrillation, in‐hospital coronary revascularization (if appropriate), hospital and admission year. Model 2: adjusted as model 1 with replacement of heart failure by left‐ventricular ejection fraction. Model 3: adjusted as model 1 with additional adjustment for high‐sensitivity cardiac troponin T (ln). p int.: p value referring to the interaction of the type of MI (MINOCA vs. MI‐CAD) on the association of CRP (ln) with adverse outcome.