TABLE 4.
Summary of studies addressing the efficacy of FMT for other disorders
| Route of | Number | ||||||
|---|---|---|---|---|---|---|---|
| Disease | Author | Study Design | Donor selection | Pretreatment | administration | of FMTs | Outcome |
| Hepatic Encephalopathy | Bajaj et al. 87 | RCT | Single selected donor | Broad‐spectrum antibiotics | Enema | 3 | Significant reduction in new HE episodes |
| Ulcerative colitis | Moayyedi et al. 88 | RCT | Multiple donors | None | Enema | 6 | Significant difference in achieving remission |
| Rossen et al. 89 | RCT | Multiple donors | Bowel lavage | Duodenal tube | 2 | No significant difference in achieving remission | |
| Parasomthy et al. 90 | RCT | Pooled donors | Bowel lavage | Colonoscopy + enema | 1 + 39 | Significant difference in achieving remission | |
| Costello et al. 91 | RCT | Pooled donors | Bowel lavage | Colonoscopy + enema | 1 + 2 | Significant difference in achieving remission | |
| Crohn's disease | Sokol et al. 92 | RCT | Multiple donors | Bowel lavage | Colonoscopy | 1 | No difference in sustained engraftment between allogeneic FMT and sham |
| Irritable bowel syndrome | Holvoet et al. 93 | RCT | Multiple donors | NA | Jejunal tube | 1 | Significant difference in symptom relief |
| Arionadis et al. 94 | RCT | Multiple donors | NA | Capsules | 3 | No difference in achieving symptom relief vs. placebo | |
| Halkjaer et al. 95 | RCT | Multiple donors | Bowel lavage | Capsules | 12 | Placebo treatment superior | |
| Johnsen et al. 96 | RCT | Multiple donors | Bowel lavage+ loperamide 2 h prior to FMT | Colonoscopy | 1 | Significant difference in symptom relief | |
| Holster et al. 97 | RCT | Multiple donors/autologous | Bowel lavage + loperamide prior to FMT | Colonoscopy | 1 | No difference in achieving symptom relief vs. autologous FMT | |
| El‐Salhy et al. 98 | RCT | Single donor | Unknown | Duodenal delivery | 1 | Significant dose dependent difference in symptom severity reduction | |
| Lahtinen et al. 99 | RCT | Single donor | Bowel lavage | Colonoscopy | 1 | No difference in symptom reduction between autologous and allogeneic FMT | |
| Eradication of MDROs | Huttner et al. 100 | RCT (open‐label) | Multiple donors | Nonabsorbable antibiotics | Capsule or nasogastric tube | 1 | Slightly decreased ESBL‐E/CPE carriage |
Abbreviations: CPE, Carbapenemase‐producing Enterobacteriaceae; ESBL, extended spectrum beta‐lactamase; FMT, faecal microbiota transplantation; MDROs, multidrug resistant organisms; NA, not available; RCT, randomised controlled trial.