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. 2021 Jun 11;53:101271. doi: 10.1016/j.molmet.2021.101271

Figure 7.

Figure 7

Partial rescue of the SMNKO mice with a nicotinamide riboside (NR) enriched diet.A) NAD+ levels in quadriceps muscle of WT and SMNKO mice fed a chow diet or a purified diet supplemented with NR (200 mg/kg body weight), (n = 2–6). Chow data are the same as in Figure S1I. Due to low and missing values for the SMNKO mice, data from WT mice are analyzed separately by a 2-way ANOVA. B) ATP levels in tibialis anterior muscle of WT and SMNKO mice fed a chow diet or an NR enriched diet (n = 2–6). Chow data are the same as in Figure 3A. Analyzed by a 3-way ANOVA. C) Average fiber area in quadriceps muscle of WT and SMNKO mice fed a chow diet or an NR enriched diet (n = 2–6). Chow data are the same as in Figure 2A. Due to unequal variance over time, data at 6 weeks of age are analyzed by 2-way ANOVA. D) Number of central nuclei in quadriceps muscle of WT and SMNKO mice fed a chow diet or NR enriched diet (n = 2–6). Chow data are the same as in Figure 2E. Due to low and missing values for the WT mice, data on SMNKO mice are analyzed by 2-way ANOVA. E) Survival curve of WT and SMNKO mice fed a chow diet or an NR enriched diet (n = 17–18). Error bars represent SEM. ∗ Difference to mice on chow diet at the same age and genotype. $ Main effect of diet within the age group. # Main effect of genotype. ¤ Difference to mice at 4 weeks of age with the same genotype and diet. & Difference to mice at 6 weeks of age with the same genotype and diet.