Table 2.
Relationship between nutritional status and isoniazid pharmacokinetic parameters among Ghanaian children with tuberculosis
| Cmax < 3 μg/ml n (%) | p-value | Cmax, μg/ml Geometric Mean (95% CI) | p-value | AUC0-8 μg.h/ml Geometric Mean (95% CI) | p-value | |
|---|---|---|---|---|---|---|
| Nutritional Status | ||||||
| ZWFH* | ||||||
| Wasting (n=24) | 4 (16.7) | 0.42 | 4.90 (4.01-6.00) | 0.55 | 16.25 (12.89-20.49) | 0.48 |
| Normal (n=24) | 3 (8.3) | 5.45 (4.01-7.40) | 18.84 (13.06-27.19) | |||
| ZWFA | ||||||
| Underweight (n=58) | 6 (10.3) | 0.42 | 5.28 (4.58-6.09) | 0.20 | 17.47 (14.74-20.70) | 0.17 |
| Normal (n=28) | 1 (3.6) | 6.16 (5.08-7.47) | 21.32 ( 17.17-26.48) | |||
| ZHFA | ||||||
| Stunting (n=56) | 6 (10.7) | 0.73 | 5.16 (4.42-6.03) | 0.14 | 16.97 (14.07-20.47) | 0.05 |
| Normal (n=43) | 3 (7.0) | 6.04 (5.28-6.91) | 21.44 (18.52-24.81) | |||
| ZBFA** | ||||||
| Malnourished (n=22) | 0 (0.0) | 0.25 | 6.21 (5.24-7.37) | 0.44 | 22.10 (17.84-27.38) | 0.24 |
| Normal (n=29) | 3 (10.3) | 5.65 (4.76-6.71) | 18.68 (15.34-22.74) |
*
ZWFH was determined for children < 5years,
**
ZBFA was determined for children ≥ 5years