Table 3.
Relationship between nutritional status and rifampin pharmacokinetic parameters among Ghanaian children with tuberculosis
| Cmax < 8 μg/ml n (%) | p-value | Cmax, μg/ml Geometric Mean (95% CI) | p-value | AUC0-8 μg.h/ml Geometric Mean (95% CI) | p-value | |
|---|---|---|---|---|---|---|
| Nutritional status | ||||||
| ZWFH* | ||||||
| Wasting (n=24) | 14 (58.3) | 0.12 | 5.62 (4.47-7.06) | 0.47 | 23.66 (18.64-30.04) | 0.33 |
| Normal (n=24) | 19 (79.2) | 4.92 (3.68-6.60) | 19.41 (13.82-27.26) | |||
| ZWFA | ||||||
| Underweight (n=58) | 38 (65.5) | 0.17 | 5.73 (4.83-6.78) | 0.37 | 23.50 (19.68-28.05) | 0.31 |
| Normal (n=28) | 14 (50.0) | 6.51 (5.21-8.14) | 27.42 (21.60-34.80) | |||
| ZHFA | ||||||
| Stunting (n=56) | 43 (76.8) | <0.01*** | 5.33 (4.43-6.42) | <0.01*** | 21.84 (17.95-26.57) | <0.01*** |
| Normal (n=43) | 18 (41.9) | 7.23 (6.43-8.13) | 31.17 (27.61-35.18) | |||
| ZBFA** | ||||||
| Malnourished (n=22) | 12 (54.6) | 0.96 | 6.68 (4.86-9.17) | 0.64 | 29.13 (21.95-38.66) | 0.74 |
| Normal (n=29) | 16 (55.2) | 7.22 (6.24-8.35) | 30.69 ( 26.15-36.02) |
*
ZWFH was determined for children < 5years,
**
ZBFA was determined for children ≥ 5years
***
statistically significant p-value.