Table 4.
Relationship between nutritional status and pyrazinamide pharmacokinetic parameters among Ghanaian children with tuberculosis
| Cmax < 20 μg/ml n (%) | p-value | Cmax, μg/ml Geometric Mean (95% CI) | p-value | AUC0-8 μg.h/ml Geometric Mean (95% CI) | p-value | |
|---|---|---|---|---|---|---|
| Nutritional Status | ||||||
| ZWFH* | ||||||
| Wasting (n=24) | 8 (33.3) | 0.37 | 22.23 (18.45-26.79) | 0.71 | 117.7 (99.70-139.0) | 0.70 |
| Normal (n=23) | 5 (21.7) | 23.33 (19.38-28.10) | 123.3 (102.5-148.2) | |||
| ZWFA | ||||||
| Underweight (n=58) | 11 (19.0) | 0.91 | 23.91 (21.43-26.69) | 0.90 | 124.0 (118.6-137.6) | 0.89 |
| Normal (n=25) | 5 (20.0) | 23.48 (18.08-30.50) | 126.3 (97.34-164.0) | |||
| ZHFA | ||||||
| Stunting (n=54) | 14 (25.9) | 0.02*** | 22.84 (19.54-26.69) | 0.02*** | 117.2 (101.0-136.1) | <0.01*** |
| Normal (n=42) | 3 (7.1) | 28.11 (25.59-30.88) | 153.9 (139.7-169.5) | |||
| ZBFA** | ||||||
| Malnourished (n=22) | 0 (0) | 0.12 | 32.76 (28.64-37.47) | 0.02*** | 172.1 (150.2-197.1) | 0.02*** |
| Normal (n=27) | 4 (14.8) | 23.64 (18.63-30.01) | 125.1 (97.93-159.7) |
*
ZWFH was determined for children < 5years,
**
ZBFA was determined for children ≥ 5years
***
statistically significant p-value.