. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Ann Neurol. 2020 Aug 5;88(4):807–816. doi: 10.1002/ana.25844

TABLE 2.

Associations between Ischemic Events, sICH, and Combined Outcomes across Different Time Categories in Univariate or Multivariate Models

Time Category	Ischemic Event, OR (95% CI), p	sICH, OR (95% CI), p	Combined, OR (95% CI), p
4–14 days	0.81 (0.52–1.27), 0.355	1.16 (0.48–2.81), 0.749	0.93 (0.65–1.35), 0.713
	0.82 (0.51–1.32), 0.415	1.24 (0.49–3.13), 0.648	0.93 (0.61–1.39), 0.707
	0.90 (0.54–1.51), 0.693^a	0.91 (0.35–2.37), 0.841	0.89 (0.59–1.35), 0.570^a
4–7 days	0.92 (0.54–1.56), 0.756	1.43 (0.54–3.75), 0.470	0.99 (0.65–1.53), 0.973
	0.94 (0.54–1.63), 0.815	1.54 (0.57–4.20), 0.397	0.96 (0.59–1.55), 0.863
	0.89 (0.49–1.64), 0.717^a	1.30 (0.43–3.89), 0.642	0.93 (0.57–1.51), 0.758^a
7–10 days	0.64 (0.33–1.26), 0.200	0.56 (0.13–2.43), 0.439	0.64 (0.36–1.11), 0.114
	0.64 (0.31–1.30), 0.217	0.72 (0.16–3.30), 0.672	0.71 (0.39–1.27), 0.250
	0.76 (0.37–1.58), 0.463^a	0.59 (0.13–2.70), 0.499	0.68 (0.38–1.24), 0.212^a
10–14 days	0.83 (0.43–1.59), 0.568	0.64 (0.15–2.78), 0.550	0.92 (0.55–1.56), 0.762
	0.83 (0.42–1.65), 0.597	0.66 (0.14–3.04), 0.592	0.95 (0.54–1.69), 0.867
	1.06 (0.52–2.17), 0.872^a	0.47 (0.10–2.18), 0.336	0.93 (0.52–1.66), 0.804^a

The first row in each category is unadjusted and the second and third rows are adjusted for covariates.

In the second row, ischemic event is adjusted for moderate or severe aortic or mitral valvular heart disease, prior stroke, cardiac thrombus, and CHA₂DS₂Vasc. sICH is adjusted for largest ischemic lesion size (<60ml vs ≥60ml), early hemorrhagic transformation, and bridging with heparin or low–molecular-weight heparin. Combined outcome is adjusted for moderate to severe aortic or mitral valvular heart disease, prior stroke, cardiac thrombus, CHA₂DS₂Vasc, largest ischemic lesion size (<60ml vs ≥60ml), early hemorrhagic transformation, and bridging therapy with heparin or low–molecular-weight heparin.

In the third row, data are adjusted for prior stroke, coronary artery disease, congestive heart failure, National Institutes of Health Stroke Scale score, moderate or severe aortic or mitral valvular heart disease, cardiac thrombus, largest ischemic lesion size (<60ml vs ≥60ml), early hemorrhagic transformation, and direct oral anticoagulant use.

CI = confidence interval; OR = odds ratio; sICH = symptomatic intracerebral hemorrhage.