Table 2.

Unadjusted event numbers and rates

Outcomes	Control (n=68)	Intervention (n=68)	P value
Coprimary
Total number of medication errors	1385	614	<0.001
Potentially lethal	0	0
Serious	1	0	<0.001
Significant	1320	586	0.001
Minor	64	28	<0.001
No error	0	0
Overall medication error rate, mean (SD)	20.4 (14.0)	9.0 (5.9)
Total number of adverse events	1446	1406	0.85
Grade 1	952	949	0.98
Grade 2	359	376	0.81
Grade 3	107	75	0.18
Grade 4	26	5	<0.001
Grade 5	1	0	1.00
Grade 3 or higher	134	80	0.04
Adverse event rate, mean (SD)	21.26 (25.24)	20.68 (18.35)	0.83
Grade 1	14.00 (15.10)	13.96 (1.47)	0.96
Grade 2	5.28 (0.94)	5.53 (0.72)	0.93
Grade 3	1.57 (0.34)	1.10 (0.22)	0.19
Grade 4	0.38 (0.15)	0.07 (0.05)	<0.001
Grade 5	0.01 (0.01)	0 (0)	1.00
Grade 3 or higher	1.97 (0.46)	1.18 (0.25)	0.04
Secondary
Total hospitalizations	74	44
Hospitalization rate (95% CI)	1.08 (0.60–1.6)	0.65 (0.40–0.94)	0.007
Total infections	86	90
Infection rate (95% CI)	1.26 (0.76–1.76)	1.32 (0.92–1.72)	0.75
Total opportunistic infections	10	13
Opportunistic infection rate (95% CI)	0.14 (0.01–0.30)	0.19 (0.09–0.30)	0.47

95% CI, 95% confidence interval.