Table 5.
Comparison of ocular surface disease index in the worse eye in eyes receiving trehalose versus standard therapy
| OSDI | Trehalose (n=192), n (%) | Standard therapy (n=192), n (%) | P |
|---|---|---|---|
| Baseline | |||
| Normal | 10 (5) | 10 (5) | 0.93 |
| Mild DED | 77 (40) | 83 (43) | |
| Moderate DED | 80 (42) | 74 (39) | |
| Severe DED | 25 (13) | 25 (13) | |
| At 4 weeks* | |||
| Normal | 35 (18) | 43 (22) | 0.27 |
| Mild DED | 101 (56) | 109 (57) | |
| Moderate DED | 50 (23) | 35 (18) | |
| Severe DED | 6 (3) | 5 (3) | |
| At 8 weeks | |||
| Normal | 48 (25) | 57 (30) | 0.38 |
| Mild DED | 132 (69) | 127 (66) | |
| Moderate DED | 10 (5) | 8 (4) | |
| Severe DED | 2 (1) | 0 |
*P<0.05 – Chi-square comparing the time points from previous time point. OSDI=Ocular surface disease index, DED=Dry eye disease