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. 2021 Jun 22;12:624753. doi: 10.3389/fimmu.2021.624753

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Copyright © 2021 Li, Wen, Chen, Wu, Liu, Li, Su and Tong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) HS altered the miRNA expression patterns of hepatocyte-derived EVs, as analyzed using NGS. The number and proportion of differentially regulated (upregulated, downregulated, and non-significant) EV miRNAs isolated from HS compared with the control (n = 3 samples/group). Numbers indicate proportions. Data base: Homo Sapiens. (B) Volcano plot representing the miRNA fold-change and RNA intensity in the HS and control hepatocyte EVs. X-axis shows miRNA fold-change (HS/Control, log2), whereas Y-axis depicted the summary of RNA intensity (LFQ intensity, lg).