Supplement Table 4. All somatic single nucleotide variant identified in discovery cohort.

Sample	NR7	NR5	NR4	NR8	R1	R3	NR6	NR1	R4	R2	NR2	R5	NR3
CDS	112	202	276	19	189	10	48	61	152	335	155	320	87
synonymous_SNP	30	53	59	5	49	6	24	17	38	92	38	91	28
missense_SNP	69	136	194	12	126	4	24	38	97	211	100	208	48
stopgain	12	6	15	1	4	0	0	5	13	18	11	11	7
stoploss	0	1	1	0	1	0	0	0	0	1	0	1	0
unknown	1	6	7	1	9	0	0	1	4	13	6	9	4
intronic	219	389	359	50	348	53	267	144	330	497	245	628	100
UTR3	13	39	34	2	22	3	14	3	18	35	14	33	11
UTR5	16	22	20	3	18	0	8	2	13	26	17	37	12
splicing	6	9	10	1	5	0	1	2	5	10	6	9	4
ncRNA_exonic	13	19	10	6	16	1	12	12	17	22	4	21	9
ncRNA_intronic	20	33	45	27	37	21	48	24	32	47	25	46	19
ncRNA_UTR3	0	0	0	0	0	0	0	0	0	0	0	0	0
ncRNA_UTR5	0	0	0	0	0	0	0	0	0	0	0	0	0
ncRNA_splicing	0	1	0	0	0	0	0	0	1	1	0	0	0
upstream	10	11	14	3	9	2	15	2	14	19	8	37	2
downstream	3	3	0	1	8	1	6	3	3	3	2	10	5
intergenic	126	122	126	82	133	87	110	101	124	136	100	146	72
Total	539	852	897	195	787	178	529	354	709	1131	577	1288	322