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. Author manuscript; available in PMC: 2021 Jul 6.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Aug 29;50(1):311–321. doi: 10.1167/iovs.08-2461

Figure 2.

Figure 2.

Ocular phenotype of VEGF120/120 mice. (A–C) E13.5 WT and VEGF120/120 heads. (D–F) Paraffin sections of E13.5 WT and VEGF120/120 mice were stained with hematoxylin-periodic acid-Schiff. (B, E) In type I VEGF120/120 mice, all the eye structures were evident but smaller. Note the reduced optic cup opening compared to WT eye. (C, F) Type II VEGF120/120 mice displayed a more severe phenotype with a closed optic cup. Retinas were present but lenses were extremely reduced with no apparent differentiation of lens epithelium or posterior lens fibers and displaying prominent retinal folding (white arrowhead and inset). Scale bar: (A–C) 1 mm; (D–F) 200 μm.