Table 2.
Genetically Predicted Exposure | N of Instrumented SNPs | Cochran’s Q Statistics P Value | MR-Egger Pleiotropy Test P Value | MR Method | OR (CKD) (95% Confidence Interval) a | P |
---|---|---|---|---|---|---|
Positive affect | 102 | 0.001 | 0.23 | Multiplicative random-effect IVW | 0.69 (0.52 to 0.91) | 0.008 |
MR-Egger | 0.34 (0.10 to 1.11) | 0.08 | ||||
Weighted median | 0.81 (0.57 to 1.16) | 0.25 | ||||
Simple median | 0.73 (0.52 to 1.03) | 0.07 | ||||
MR-PRESSO (identified 1 outlier SNPs) | 0.72 (0.55 to 0.94) | 0.02 | ||||
Life satisfaction | 76 | 0.01 | 0.05 | Multiplicative random-effect IVW | 0.77 (0.57 to 1.04) | 0.09 |
MR-Egger | 0.16 (0.03 to 0.79) | 0.03 | ||||
Weighted median | 0.84 (0.57 to 1.22) | 0.36 | ||||
Simple median | 0.90 (0.62 to 1.29) | 0.56 | ||||
MR-PRESSO (identified 1 outlier SNPs) | 0.82 (0.60 to 1.13) | 0.18 | ||||
Depressive symptom | 125 | <0.001 | 0.07 | Multiplicative random-effect IVW | 1.45 (1.07 to 1.96) | 0.02 |
MR-Egger | 5.21 (1.26 to 21.62) | 0.02 | ||||
Weighted median | 1.54 (1.07 to 2.22) | 0.02 | ||||
Simple median | 1.50 (1.03 to 2.18) | 0.03 | ||||
MR-PRESSO (identified 0 outlier SNPs) | NA | NA | ||||
Neuroticism | 133 | <0.001 | 0.11 | Multiplicative random-effect IVW | 1.16 (0.96 to 1.41) | 0.12 |
MR-Egger | 2.46 (0.97 to 6.26) | 0.06 | ||||
Weighted median | 1.15 (0.91 to 1.47) | 0.24 | ||||
Simple median | 1.08 (0.85 to 1.37) | 0.53 | ||||
MR-PRESSO (identified 1 outlier SNP) | 1.13 (0.94 to 1.36) | 0.20 |
IVW, inverse variance weighted.
The effect sizes were from the genetic predisposition scaled to a z score in the previous model-averaging genome-wide association meta-analysis setting phenotype variance to 1.