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. 2021 Jun 1;32(6):1484–1496. doi: 10.1681/ASN.2020071086

Table 2.

Summary-level MR results for the causal estimates from psychologic wellbeing on risk of CKD in the CKDGen data

Genetically Predicted Exposure N of Instrumented SNPs Cochran’s Q Statistics P Value MR-Egger Pleiotropy Test P Value MR Method OR (CKD) (95% Confidence Interval) a P
Positive affect 102 0.001 0.23 Multiplicative random-effect IVW 0.69 (0.52 to 0.91) 0.008
MR-Egger 0.34 (0.10 to 1.11) 0.08
Weighted median 0.81 (0.57 to 1.16) 0.25
Simple median 0.73 (0.52 to 1.03) 0.07
MR-PRESSO (identified 1 outlier SNPs) 0.72 (0.55 to 0.94) 0.02
Life satisfaction 76 0.01 0.05 Multiplicative random-effect IVW 0.77 (0.57 to 1.04) 0.09
MR-Egger 0.16 (0.03 to 0.79) 0.03
Weighted median 0.84 (0.57 to 1.22) 0.36
Simple median 0.90 (0.62 to 1.29) 0.56
MR-PRESSO (identified 1 outlier SNPs) 0.82 (0.60 to 1.13) 0.18
Depressive symptom 125 <0.001 0.07 Multiplicative random-effect IVW 1.45 (1.07 to 1.96) 0.02
MR-Egger 5.21 (1.26 to 21.62) 0.02
Weighted median 1.54 (1.07 to 2.22) 0.02
Simple median 1.50 (1.03 to 2.18) 0.03
MR-PRESSO (identified 0 outlier SNPs) NA NA
Neuroticism 133 <0.001 0.11 Multiplicative random-effect IVW 1.16 (0.96 to 1.41) 0.12
MR-Egger 2.46 (0.97 to 6.26) 0.06
Weighted median 1.15 (0.91 to 1.47) 0.24
Simple median 1.08 (0.85 to 1.37) 0.53
MR-PRESSO (identified 1 outlier SNP) 1.13 (0.94 to 1.36) 0.20

IVW, inverse variance weighted.

a

The effect sizes were from the genetic predisposition scaled to a z score in the previous model-averaging genome-wide association meta-analysis setting phenotype variance to 1.