Table 3.

Summary-level MR results for the causal estimates from psychologic wellbeing on eGFR change (%) in the CKDGen data

Genetically Predicted Exposure	N of SNPs of the Genetic Instrument	Cochran’s Q Statistics P Value	MR-Egger Pleiotropy Test P Value	MR Method	Beta (eGFR change, %) (95% Confidence Interval) a	P
Positive affect	102	<0.001	0.83	Multiplicative random-effect IVW	1.50 (0.09 to 2.93)	0.04
				MR-Egger	2.18 (−3.86 to 8.59)	0.49
				Weighted median	−0.03 (−1.45 to 1.41)	0.97
				Simple median	0.61 (−0.86 to 2.11)	0.42
				MR-PRESSO (identified 1 outlier SNPs)	1.35 (0.01 to 2.71)	0.05
Life satisfaction	76	<0.001	0.04	Multiplicative random-effect IVW	1.25 (−0.30 to 2.83)	0.11
				MR-Egger	10.14 (1.54 to 19.46)	0.02
				Weighted median	0.77 (−0.74 to 2.31)	0.32
				Simple median	0.74 (−0.70 to 2.21)	0.32
				MR-PRESSO (identified 1 outlier SNPs)	1.12 (−0.23 to 2.49)	0.11
Depressive symptom	125	<0.001	0.001	Multiplicative random-effect IVW	−2.18 (−3.61 to −0.72)	0.003
				MR-Egger	−12.33 (−18.06 to −6.20)	<0.001
				Weighted median	−1.27 (−2.80 to 0.29)	0.11
				Simple median	−1.35 (−2.84 to 0.17)	0.08
				MR-PRESSO (identified 0 outlier SNPs)	−1.78 (−3.09 to −0.45)	0.01
Neuroticism	133	<0.001	0.02	Multiplicative random-effect IVW	−0.88 (−1.87 to 0.13)	0.09
				MR-Egger	−6.48 (−10.87 to −1.87)	0.007
				Weighted median	−0.71 (−1.68 to 0.27)	0.15
				Simple median	−0.67 (−1.65 to 0.32)	0.18
				MR-PRESSO (identified 1 outlier SNP)	−0.85 (−1.73 to 0.05)	0.07

IVW, inverse variance weighted.

^aThe effect sizes were from the genetic predisposition scaled to a z score in the previous model-averaging genome-wide association meta-analysis setting phenotype variance to 1.