Table 5.

Summary-level MR results for the causal estimates of kidney function on psychologic wellbeing spectra

Outcome	N of SNPs of the Genetic Instrument	Cochran’s Q Statistics P Value	MR-Egger Pleiotropy Test P Value	MR Method	Beta (95% Confidence Interval) a	P
Positive affect	30	0.03	0.10	Multiplicative random-effect IVW	0.02 (−0.15 to 0.20)	0.79
				MR-Egger	0.49 (−0.07 to 1.05)	0.10
				Weighted median	0.08 (−0.12 to 0.29)	0.41
				Simple median	0.02 (−0.19 to 0.24)	0.83
				MR-PRESSO (identified 0 outlier SNPs)	NA	NA
Life satisfaction	30	0.24	0.16	Multiplicative random-effect IVW	0.07 (−0.12 to 0.26)	0.45
				MR-Egger	0.49 (−0.10 to 1.08)	0.12
				Weighted median	0.13 (−0.11 to 0.37)	0.29
				Simple median	0.06 (−0.18 to 0.31)	0.62
				MR-PRESSO (identified 0 outlier SNPs)	NA	NA
Depressive symptom	30	0.02	0.06	Multiplicative random-effect IVW	−0.02 (−0.15 to 0.12)	0.82
				MR-Egger	−0.43 (−0.87 to 0.01)	0.07
				Weighted median	−0.08 (−0.25 to 0.09)	0.37
				Simple median	−0.02 (−0.18 to 0.14)	0.34
				MR-PRESSO (identified 1 outlier SNPs)	−0.04 (−0.16 to 0.09)	0.54
Neuroticism	30	0.02	0.08	Multiplicative random-effect IVW	−0.03 (−0.25 to 0.18)	0.76
				MR-Egger	−0.66 (−1.36 to 0.05)	0.08
				Weighted median	−0.11 (−0.36 to 0.14)	0.39
				Simple median	−0.03 (−0.28 to 0.23)	0.82
				MR-PRESSO (identified 1 outlier SNPs)	−0.07 (−0.27 to 0.13)	0.49

^aThe effect sizes are from the genetic predisposition for a log-transformed eGFR to the summary statistics for the wellbeing dimensions reporting effects sizes in units toward a z score in the previous model-averaging genome-wide association meta-analysis setting phenotype variance to 1.