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Myeloid IRF4 deficiency protected against renal fibrosis in UUO. Male IRF4f/f (WT) and LysM-Cre IRF4f/f (MΦ IRF4−/−) mice underwent UUO for 7 days. (A) Quantitative PCR analysis showed lower renal mRNA levels of profibrotic and fibrotic components, including α-SMA, CTGF, TGF-β1, TGF-β2, collagen I (col I), col III, col IV, and fibronectin (FN) in MΦ IRF4−/− mice. **P<0.01, ***P<0.001; n=8. (B) Sirius red staining showed less renal fibrosis in MΦ IRF4−/− mice. ***P<0.001, n=4.
