Figure 6.

MMF and IL-6 neutralization prevent the accumulation of cytokines in the kidney. (A and E) IL-1β, (B and F) TNFα, (C and G) IL-6, and (D and H) IL-17A were evaluated in kidney homogenates by ELISA. Data are expressed as dot plots. Horizontal bars represent the mean±SD (n=6 per group). *P<0.05, **P<0.01, ***P<0.001 by two-way ANOVA. Panels (A–D) show renal cytokine levels in mice treated with MMF. Panels (E–H) show renal cytokine levels in mice treated with an anti–IL-6 neutralizing antibody (aIL-6). N/D, not detected; Veh, vehicle.