Table 3.

Male, 34-week-old, diabetic mice and their respective nondiabetic controls received either an MS or HS diet for 4 weeks in the presence of neutralizing antibody anti–IL-6 (saline) or isotype control (IgG1 dissolved in saline)

Parameters	db/+			db/db
	MS and IgG1	HS and IgG1	HS and Anti–IL-6	MS and IgG1	HS and IgG1	MS and Anti–IL-6
Body wt (g)	34±3	35±4	37±3	60±6 a	61±2 a	54±3 a
Blood glucose (mg/dl)	119±17	105±29	112±18	284±39 a	271±54 a	259±49 a
Plasma insulin (ng/ml)	0.6±0.3	1.7±0.4	1.8±0.3	15±6 a	16±8 a	16±7 a

Body weight, blood glucose and plasma insulin were measured at the end of the experiment after a 4-h fasting. Data are expressed as mean±SD. MS consisted of 0.7% wt/wt NaCl; HS consisted of 4% wt/wt NaCl.

^a P<0.001 versus the corresponding db/+ group by two-way ANOVA.