Table 3.
Graft survival, RMST, and DMRST at 5- and 10-yr post-biopsy, according to each cluster and each Banff diagnostic category (n=3510)
| Banff Diagnosis | % Graft Survival At 5 Yr (%) | % Graft Survival At 10 Yr (%) | RMST At 5 Yr Postbiopsy, (95% CI) | RMST at 10 Yr Postbiopsy, (95% CI) | HR Versus No, (95% CI) | HR P Value Versus Yr | DRMST At 5 Yr Versus No Rejection, (95% CI) | DRMST At 10 Yr Versus No Rejection, (95% CI) |
|---|---|---|---|---|---|---|---|---|
| No rejection | 89.5 | 51.0 | 4.74 (4.63 to 4.85) | 9.01 (8.56 to 9.46) | — | — | — | — |
| Borderline changes | 83.1 | 42.3 | 4.66 (4.47 to 4.85) | 8.87 (8.04 to 9.7) | 1.27 (0.88 to 1.84) | 0.201 | 0.08 (-0.06 to 0.22) | 0.14 (-0.24 to 0.53) |
| TCMR | 75.5 | 41.2 | 4.50 (4.27 to 4.74) | 8.46 (7.7 to 9.22) | 1.66 (1.17 to 2.36) | 0.004 | 0.24 (0.05 to 0.42) | 0.55 (0.09 to 1.01) |
| ABMR | 70.2 | 22.0 | 4.26 (3.89 to 4.63) | 7.63 (6.25 to 9.02) | 2.63 (1.65 to 4.21) | <0.0001 | 0.48 (0.15 to 0.81) | 1.38 (0.51 to 2.25) |
| Mixed borderline rejection | 63.6 | 8.3 | 3.55 (4.06 to 4.57) | 6.74 (4.06 to 7.72) | 4.26 (2.29 to 7.94) | <0.0001 | 0.67 (0.06 to 1.28) | 2.13 (0.65 to 3.61) |
| Mixed rejection | 59.2 | 20.5 | 3.98 (3.48 to 4.48) | 7.03 (5.74 to 8.32) | 3.24 (2.08 to 5.05) | <0.0001 | 0.76 (0.34 to 1.18) | 1.98 (1.00 to 2.96) |
| Average | — | — | — | — | — | 0.45 (0.11 to 0.78) | 1.24 (0.40 to 2.07) | |
| Weighted average | — | — | — | — | — | 0.29 (0.06 to 0.53) | 0.72 (0.14 to 0.93) | |
| Cluster | % Graft Survival at 5 Yr (%) | % Graft Survival at 10 Yr (%) | RMST at 5 Yr Postbiopsy (95% CI) | RMST at 10 Yr Postbiopsy (95% CI) | HR Versus Cluster 1 | HR P Value Versus Cluster 1 | DRMST At 5 Yr Versus Cluster 1 (95% CI) | DRMST At 10 Yr Versus Cluster 1 (95% CI) |
| Cluster 1 | 90.9 | 54.6 | 4.76 (4.65 to 4.87) | 9.09 (8.63 to 9.56) | — | — | — | — |
| Cluster 2 | 77.6 | 33.3 | 4.42 (4.01 to 4.84) | 8.28 (6.98 to 9.59) | 1.98 (1.15 to 3.43) | 0.014 | 0.34 (0.02 to 0.70) | 0.81 (−0.03 to 1.65) |
| Cluster 3 | 75.0 | 39.8 | 4.54 (4.30 to 4.79) | 8.56 (7.75 to 9.36) | 1.72 (1.17 to 2.52) | 0.005 | 0.22 (0.02 to 0.41) | 0.53 (0.05 to 1.02) |
| Cluster 4 | 70.0 | 28.6 | 4.23 (3.87 to 4.58) | 7.67 (6.36 to 8.98) | 2.84 (1.88 to 4.30) | <0.0001 | 0.53 (0.24 to 0.82) | 1.42 (0.69 to 2.15) |
| Cluster 5 | 62.3 | 6.1 | 4.06 (3.48 to 4.64) | 6.84 (5.04 to 8.64) | 4.17 (2.48 to 7.03) | <0.0001 | 0.70 (0.26 to 1.14) | 2.25 (1.07 to 3.42) |
| Cluster 6 | 50.0 | 6.2 | 3.96 (3.43 to 4.48) | 6.78 (4.96 to 8.59) | 4.37 (2.59 to 7.35) | <0.0001 | 0.80 (0.31 to 1.29) | 2.31 (1.11 to 3.52) |
| Average | — | — | — | — | — | 0.52 (0.17 to 0.87) | 1.46 (0.58 to 2.35) | |
| Weighted average | — | — | — | — | — | 0.46 (0.09 to 0.69) | 1.25 (0.48 to 2.01) |