Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Graphic of the α subunit of the BK channel, annotated with all known patient mutations. The S0-S6 transmembrane domains represent the pore-forming portion of the subunit, while S7-S8 and S9-S10 comprise the Ca2+-sensitive RCK1 and RCK2 domains respectively. The + symbols in domains S2-S4 mark the location of residues conferring voltage-sensitivity. Mutation types are denoted by color. C413Y/N449fs is a double mutation in a single patient
