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. 2021 Jul 5;10(1):322–337. doi: 10.1080/21623945.2021.1945210

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Hypoxic ADSCs-derived EVs promoted the differentiation of cartilage stem/progenitor cell

The expression of these chondrocyte-specific genes (aggrecan, type II collagen, and Sox-9) cultured in solution containing 50 μg/mL was significantly upregulated (p < 0.05), while the expression of these chondrocyte-specific genes in the control groups remained very low. In addition, the RUNX2, collagen 10a1, and MMP13 mRNA expression was significantly down-regulated when cultured in solution containing hypoxic ADSCs-derived EVs (50 μg/mL) (p < 0.05)