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. 2021 Jun 22;12:696635. doi: 10.3389/fphar.2021.696635

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Copyright © 2021 Xie, Shen, Zhao, Ye, Ge and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myocardial fibrosis and cardiac diastolic dysfunction (DD) are ameliorated by the knockdown of JNK or p38 MAPK (A) Massonʼs trichrome staining of heart tissue (original magnification ×400). The columns show the differences in collagen accumulation. Scale bars, 50 μm (B) Echo-Doppler traces for transmitral flow (C) Transmitral pulsed-wave Doppler measurements of E/A, E Dec t, and IVRT (D) Hemodynamic parameters: −dP/dt min and the time constant, Tau. The columns show the differences in left ventricular DD and hemodynamic parameters. Data are presented as mean ± SEM (n = 6). p-values were calculated using one-way ANOVA with Tukey multiple comparison test. *p < 0.05, compared to the db/db mice groups.