FIGURE 8.

Ivabradine and zatebradine ameliorate diabetes-induced cardiac diastolic dysfunction (DD) (A) Mice were administered ivabradine or zatebradine at the indicated doses and echo-Doppler traces for the transmitral flow were recorded (B) Mice were treated as described in (A) and transmitral pulsed-wave Doppler measurements of E/A, E Dec t, and IVRT were obtained (C) Mice were treated as described in (A) and the hemodynamic parameters −dP/dt min and Tau were measured. The columns show the differences in left ventricular DD and hemodynamic parameters. Data are presented as mean ± SEM (n = 6). p-values were calculated using one-way ANOVA with Tukey multiple comparison test. *p < 0.05, compared to the Control group; ^# p < 0.05, compared to the db/db mouse group.