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. 2021 Jun 22;12:697720. doi: 10.3389/fphar.2021.697720

TABLE 2.

PVAT-generated autocrine and paracrine factors.

Anti-inflammatory factors Pro-inflammatory factors
cPVAT Adiponectin Iacobellis et al. (2005), Cheng et al. (2008), Chatterjee et al. (2009), Spiroglou et al. (2010) MCP-1 (CCL2), IL-8, IL-6, Leptin, MIP-1α (CCL3) Chatterjee et al. (2009)
Omentin Gaborit et al. (2015) TNF-α, IL-1β Mazurek et al. (2003)
IL-10 Gruzdeva et al. (2019), Numaguchi et al. (2019) IL-13 Vianello et al. (2019)
Visfatin, TNF-α Cheng et al. (2008)
Chemerin, Vispin Spiroglou et al. (2010)
Apelin Toczylowski et al. (2019)
Plasminogen activator inhibitor-1, Resistin Langheim et al. (2010)
tPVAT Adiponectin Chatterjee et al. (2009) IL-6, TNF-α, RANTES (CCL5), MCP-1 (CCL2) Manka et al. (2014), Xiong et al. (2018)
IL-10, IL-4 Dobrian et al. (2015) IL-17A Smith et al. (2010)
IL12p40, CXCL10, CX3CL1, CCL2, CXCL16 Dobrian et al. (2015)
Leptin Chatterjee et al. (2009)
Resistin Jung et al. (2006)
Visfatin Wang et al. (2009)
aPVAT Adiponectin Kostopoulos et al. (2014), Horimatsu et al. (2018) IL-1, IL-6 Lohmann et al. (2009)
IL-10 (Sakamoto et al. (2014) MIP-1α (CCL3) Moos et al. (2005)
RANTES Sakamoto et al. (2014)
IL-8, MCP-1Henrichot et al. (2005)
Leptin Police et al. (2009)
Platelet-derived growth factor-D Zhang et al. (2018)
Resistin and visfatin Spiroglou et al. (2010), Park et al. (2014)
Chemerin Spiroglou et al. 2010)
White PVAT (mesenteric, femoral, common carotid) Adiponectin Schmid et al. (2011), Weston et al. (2013) IFN-γ, IL-17 Smith et al. (2010)
IL-10 Kassan et al. (2011) MCP-1, TNF-α, IL-6, Plasminogen activator inhibitor-1 Takaoka et al. (2010)
CCL2, CCL5 and CX3CL1, IL-1β, MIP-1α Lohmann et al. (2009)

CX3CL1, C-X3-C motif chemokine ligand 1; CXCL10, C-X-C motif chemokine ligand 10; CXCL16, C-X-C motif chemokine ligand 16; IFN-γ, Interferon-γ; IL, interleukin; MCP-1 (CCL2), monocyte chemoattractant protein-1 (C-C motif chemokine ligand 2); MIP-1α (CCL3), macrophage inflammatory protein-1α (C-C motif chemokine ligand 3); RANTES (CCL5), Regulated upon activation, normal T cell expressed and presumably secreted (C-C motif chemokine ligand 5); TNF-α, Tumor necrosis factor-α.