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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: ACS Sustain Chem Eng. 2021 Mar 4;9(10):3909–3919. doi: 10.1021/acssuschemeng.0c09139

Table 1.

Details of Selected 14 Bioassays

Targets PubChem AID No. compounds Assay typesa Descriptions
MOR 152239 35 B, IC50 Binding affinity against MOR using [3H] DAMGO
445095 40 B, Ki Displacement of [3H] DAMGO from MOR
625163 36 B, Ki DrugMatrix: MOR binding using [3H] diprenorphine
779594 18 F, EC50 Functional activity at MOR: β-arrestin2 recruitment
779596 31 F, EC50 Functional activity at MOR: forskolin-stimulated cAMP accumulation
1344502 37 F, EC50 [35S] GTPγS functional assay at MOR
KOR 147859 39 B, IC50 Binding affinity against KOR using [3H] U69593
410720 27 B, Ki Displacement of [3H] U69593 form KOR
1344503 43 F, EC50 [35S] GTPγS functional assay at KOR
DOR 273132 19 B, Ki Displacement of [3H]Cl-DPDPE from DOR
273143 22 F, IC50 [35S] GTPγS functional assay at DOR
NOR 306450 40 B, Ki Displacement of [125I] nociceptin from nociceptin receptor
Serotonin 625217 118 B, Ki DrugMatrix: Serotonin 5-HT2B binding using [3H] LSD
Dopamine 625253 58 B, Ki DrugMatrix: Dopamine D2L binding using [3H] spiperone
a

B: binding affinity assays, F: functional assays.