Table 1.
Associations of ACE2, DPP4, TMPRSS2, and LY6E with 12 disease classes derived from EHR data.
| Disease Phenotype | Gene | Cases | Controls | Carrier Controls | Carrier Cases | SKAT P | Burden P | Burden OR | Burden SE | 95% CI | Dataset |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hepatic Encephalopathy | ACE2 | 97 | 8045 | 441 | 5 | 1.1E-12 | 0.0043 | 5.73 | 0.61 | 0.55 – 2.94 | AA |
| Respiratory Syncytial Virus Infectious Disease | DPP4 | 56 | 6392 | 85 | 1 | 6.8E-07 | 0.1221 | 6.06 | 1.17 | −0.48 – 4.09 | AA |
| Respiratory Failure | TMPRSS2 | 199 | 6392 | 11 | 2 | 2.3E-06 | 0.0124 | 7.31 | 0.80 | 0.43 – 3.55 | AA |
| Respiratory Failure | ACE2 | 199 | 6392 | 351 | 12 | 9.0E-05 | 0.0509 | 3.10 | 0.58 | 0 – 2.26 | AA |
| Upper Respiratory Tract Disease | DPP4 | 144 | 6392 | 85 | 3 | 2.5E-04 | 0.0978 | 4.16 | 0.86 | −0.26 – 3.11 | AA |
| Respiratory Syncytial Virus Infectious Disease | TMPRSS2 | 56 | 6392 | 11 | 1 | 3.9E-04 | 0.0217 | 11.63 | 1.07 | 0.36 – 4.55 | AA |
| Pneumonia | LY6E | 1120 | 6392 | 7 | 5 | 1.0E-02 | 0.0108 | 6.09 | 0.71 | 0.42 – 3.19 | AA |
| Respiratory Syncytial Virus Infectious Disease | ACE2 | 56 | 6392 | 351 | 7 | 1.3E-02 | 0.1857 | 3.85 | 1.02 | −0.65 – 3.34 | AA |
| Lower Respiratory Tract Disease | TMPRSS2 | 693 | 6392 | 7 | 1 | 3.4E-02 | 0.1541 | 2.59 | 0.67 | −0.36 – 2.26 | AA |
| Pneumonia | TMPRSS2 | 1120 | 6392 | 11 | 4 | 4.8E-02 | 0.2029 | 2.23 | 0.63 | −0.43 – 2.04 | AA |
| Hepatic Coma | ACE2 | 16 | 6817 | 318 | 1 | 4.3E-31 | 0.0019 | 10.45 | 0.76 | 0.87 – 3.83 | EA |
| Respiratory Syncytial Virus Infectious Disease | ACE2 | 40 | 5859 | 274 | 3 | 2.3E-07 | 0.1650 | 3.61 | 0.92 | −0.53 – 3.1 | EA |
| Cirrhosis Of Liver | ACE2 | 10 | 6817 | 43 | 1 | 1.8E-04 | 0.0837 | 9.40 | 1.30 | −0.3 – 4.78 | EA |
| Acute Myocardial Infarction | LY6E | 396 | 6494 | 8 | 1 | 1.8E-02 | 0.2936 | 3.65 | 1.23 | −1.12 – 3.71 | EA |