Skip to main content
[Preprint]. 2021 Aug 7:2021.06.28.21259529. Originally published 2021 Jul 1. [Version 2] doi: 10.1101/2021.06.28.21259529

Figure 5. Natural selection signatures of TMPRSS2.

Figure 5.

(A) The result of the MK-test for TMPRSS2 in the pooled dataset. Non-syn indicates non-synonymous variants; Syn indicates synonymous variants. “Fixed” denotes variants that were fixed between the human and the Chimpanzee; “Poly” represents polymorphic variants within human populations. OR, odds ratio. The transcript ENST00000398585.7 was used for calculation. (B) Illustration of locations of variants that are divergent between the human and Chimpanzee lineages on the TMPRSS2 protein domains. Boxes denote the protein domains of TMPRSS2. Red lines represent non-synonymous variants that occurred in the corresponding domains of TMPRSS2, with the amino acids and positions of the Human and the Chimpanzee annotated at the bottom of the lines. Blue lines denote synonymous variants. TM, transmembrane domain; LDLRA, LDL-receptor class A; SRCR, scavenger receptor cysteine-rich domain 2; Peptidase S1, Serine peptidase.