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. 2021 Jul 2;14:3991–4003. doi: 10.2147/OTT.S294965

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© 2021 Hou et al.

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LINC00504 was associated with miR-140-5p in SKBR3 and MDA-MB-231 cells. (A) The potential binding sites between LINC00504 and miR-140-5p and the mutant in the seed region. (B) The expression of miR-140-5p was detected in sh-control- or sh-LINC00504-transfected cells. (C) Luciferase reporter assays were performed by transfecting LINC00504-WT or LINC00504-Mut constructs into SKBR3 and MDA-MB-231 cells with miR-NC mimics or miR-140-5p. (D and E) SKBR3 and MDA-MB-231 cells were transfected with miR-NC mimics or miR-140-5p mimics, followed by the assessment of LINC00504 mRNA enrichment with anti-Ago2 by qRT-PCR. Anti IgG served as the control. (F) Relationship between the levels of LINC00504 and miR-140-5p in breast cancer tissues. *P<0.05/**P<0.01.