TABLE 2.

Candidate SNP markers of rheumatoid arthritis (RA) that are located near TBP-sites of human gene promoters as predicted in this work, in comparison with genome-wide patterns.

Data: GRCh38 (Zerbino et al., 2015) dbSNP build 151 (Day, 2010)				Result	Neutral drift (Haldane, 1957; Kimura, 1968; Kasowski et al., 2010)			H0: ↑↓-equivalence
No.	SNPs	NG	NS	NR	N>	N<	p(H0: N> < N<)	N↑	N↓	p(H0: N↑≡N↓)
1	Whole-genome norm for SNPs of TBP-sites (The 1000 Genomes Project Consortium (GPC) et al., 2012)	104	105	103	200	800	>0.99	–	–	–
2	Clinical SNP markers of diseases at TBP-sites (Ponomarenko et al., 2015)	33	203	51	14	37	>0.99	–	–	–
3	Candidate SNP markers of RA near clinical SNP markers of diseases at TBP-sites (Chadaeva I. V. et al., 2019)	18	225	42	12	30	>0.99	32	10	<10–4
4	Candidate SNP markers of RA near clinical SNP markers of diseases at TBP-sites (this work)	25	603	154	84	70	>0.15	96	58	<10–2
5	Candidate SNP markers of RA near TBP-sites of the genes most often associated with RA (this work)	10	466	69	46	23	<10–2	42	27	<0.05
6	Candidate SNP markers of RA near TBP-sites of immunostimulatory genes (this work)	8	479	114	71	43	<0.01	71	43	<10–2
7	Candidate SNP markers of RA near TBP-sites of immunosuppressive genes (this work)	25	928	179	104	75	<0.025	70	109	<10–2
8	Total	68	1896	516	–	–	–	–	–	–

Rheumatoid arthritis (RA): contribute to (↑) and relieve (↓). N_G and N_S: total numbers of the human genes and of their SNPs meeting the criteria of this study. N_R: the total number of the candidate SNP markers increasing (N_>) or decreasing (N_<) the affinity of TATA-binding protein (TBP) for these promoters studied in this work. N_]↑ and N_↓: total numbers of the candidate SNP markers that can contribute to or relieve RA, respectively. P(H₀): the estimate of probability for the acceptance of this H₀ hypothesis, according to a binomial distribution. TBP-site: TBP-binding site.