TABLE 4.

Correlations between the effects of codirected changes in the expression of orthologous genes on rheumatoid arthritis (RA) in humans and during the divergence of domestic and wild animals from their nearest common ancestor.

Animals	Humans	Effect of gene expression changes on RA		Binomial distribution	χ2-test		Fisher’s exact test, p
		Contribute to (↑)	Relieve (↓)		χ2	p
Effect of gene expression changes during divergence from the nearest common ancestor	Domestic	10	1	<10–2	9	10–2	0.05
	Wild	3	8	>0.1