Table 1. Boolean dependence relations between molecules of the signaling cascades presented in Fig 2, and the corresponding references.

Node	Dependence Relation	Reference
Integrin	External signal (Integrin binding)	[45]
RTK	External signal (VEGF binding)	[26,27]
E-Cadherin	External signal (cadherin binding)	[47–49]
Wnt	External signal (Frizzled receptor)	[55–58]
ß-Catenin	Wnt Or Akt And Not cadherin AND Not APC	[59,60]
APC	External signal	[40]
Grb-2/Sos	RTK And Scr	[62]
Src	FAK	[63,64]
FAK	ITG	[64]
Rho-A	FAK	[64]
ROCK	Rho-A	[65,66]
Rac-1	PI3K And Not Rho-A	[42,43]
Ras	Grb-2/Sos And Not NF1	[62,67,68]
NF1	External signal	[41]
Raf-1	Ras	[69–71]
MEK1/2	Raf-1 Or Rac-1	[69,72]
ERK1/2	MEK1/2	[69,72]
RSK	ERK 1/2	[73,74]
TSC	Not RSK Or Not Akt	[74,75]
mTORC	Not TSC	[76]
MNK	ERK 1/2	[77]
eIF4E	MNK	[78]
MSK	ERK 1/2	[79]
Fos	MSK And RSK	[80,81]
Myc	ERK 1/2 Or ß-Catenin	[82,83]
PI3K	Ras	[69]
Akt	PI3K	[84,85]
eNOS	Akt	[86]
NO	eNOS	[87]
Caspase	Not NO	[85]
Mdm2	Akt	[88]
p53	Not Mdm2	[89]
Actin	ROCK Or Rac-1	[43]
SNAIL	ß-Catenin	[90]
Cell growth	eIF4E Or mTORC	[76,78]
Cell Proliferation	Fos And Myc	[69,73,91]
Cell Apoptosis	Caspase Or p53	[88,92]
Cell Migration	Actin And SNAIL	[43,90]