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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Ann Neurol. 2021 Feb 24;89(5):952–966. doi: 10.1002/ana.26043

Figure 2. Anti-ApoE ASO treatment markedly reduces neurodegeneration in 9 month old P301S/ApoE4 mice.

Figure 2.

(A) Representative images of brain sections from 9-month-old cASO and anti-ApoE ASO-treated P301S/ApoE4 mice brain sections stained with cresyl violet. Scale bar: 0.5 mm. (B) Volumes of piriform/entorhinal cortex, hippocampus and lateral ventricle (LV) in 9-month-old mice. N=12/group. Student`s t-test. *p<0.05. (C) Representative images of the dentate gyrus (DG) area of control and ASO-treated animals. Scale bar: 100 μm. (D) Volume (left) and thickness (right) of dentate gyrus granule cell layer of 9-month-old mice. N=12/group. Student`s t-test. **p<0.01; ***p<0.001. (E) Correlation between granule cell layer thickness and hippocampal volume in 9-month-old P301S/ApoE4 mice. N=24 independent animals. Pearson`s correlation test, R2=0.3605, p=0.002. All data represented as mean ± SEM.