Four best performing RNA signatures for discriminating between controls and test-positive participants at the time of SARS-CoV-2-positive PCR test
(A) Z scores for each RNA signature in the test-negative control group and in the test-positive control group, stratified by time relative to first SARS-CoV-2-positive PCR test. Convalescent samples were collected at study week 24. AUROC (95% CI) are for discriminating between test-negative controls and test-positive participants at the time of first SARS-CoV-2-positive PCR test (0 weeks). (B) Z scores versus contemporaneous PCR cycle threshold for SARS-CoV-2 open reading frame 1, with Spearman rank correlation coefficients. AUROC=area under the receiver operating characteristic curve.