Table 1.

Electroretinograph analysis of SCA7 mice

		5 weeks (b-wave, µV)			10 weeks (b-wave, µV)				15 weeks (b-wave, µV)				23 weeks (b-wave, µV)				Two-way repeated-measures ANOVAa
		WT	SCA7	p	WT	SCA7	p	%b	WT	SCA7	p	%b	WT	SCA7	p	%b	G	A	GxA
Photopic (Cd·s·m-2)	1	66.2 ± 22.8	65.8 ± 24.5	0,971	66.4 ± 16.4	42.4 ± 17.1	0,035	36%	75.6 ± 16.8	28.2 ± 13.6	<0.001	63%	39.8 ± 13.3	6.4 ± 6	0,004	84%	<0.001	< 0.001	0,046
	3	132 ± 31.9	150 ± 41.5	0,384	132.4 ± 20.5	90.6 ± 42.7	0,049	32%	134 ± 28.3	52.8 ± 34.9	<0.001	61%	90.4 ± 32	14.8 ± 16.9	<0.001	84%	0,002	< 0.001	0,009
	10	167.6 ± 41.3	174.8 ± 25.2	0,776	164.8 ± 26.1	131.4 ± 58.1	0,194	20%	171.4 ± 45.1	83.6 ± 53	0,001	51%	124.4 ± 28.9	20.8 ± 23.8	<0.001	83%	0,005	< 0.001	0,011
Flicker (Hz)	2	135.8 ± 24.2	138 ± 35.1	0,910	137.6 ± 12	86.4 ± 50.9	0,012	37%	136.4 ± 30.3	47.2 ± 32.3	<0.001	65%	96.6 ± 26.4	12.4 ± 14	<0.001	87%	<0.001	< 0.001	0,008
	5	109.8 ± 27	135 ± 52.5	0,211	125.4 ± 13.5	68.4 ± 39	0,007	45%	124.4 ± 28.1	43 ± 29.6	<0.001	65%	83.2 ± 27.5	11.6 ± 13.5	0,001	86%	0,003	< 0.001	0,002
	10	78.6 ± 22.3	104.2 ± 49.9	0,128	85.4 ± 9.3	52 ± 28.9	0,050	39%	89.4 ± 18.7	37 ± 25	0,003	59%	59 ± 16.7	11.2 ± 13.7	0,007	81%	0,026	< 0.001	0,004
	20	33 ± 14.8	48.8 ± 22.5	0,101	34.6 ± 11.8	23.6 ± 15.3	0,248	32%	48 ± 17.6	23.4 ± 13.8	0,013	51%	27.4 ± 12.1	0	0,006	100%	0,067	0,001	0,006
	25	24.4 ± 12	39.2 ± 29.6	0,080	23.8 ± 6.7	15.2 ± 11.1	0,301	36%	36 ± 10.4	15.8 ± 4.2	0,019	56%	13 ± 4.9	0	0,122	100%	0,169	0,001	0,027

^aG, Genotype; A, age; GxA, genotype × age. p values, post hoc Bonferroni test. Single eye of n = 5 mice.

^bPercentage of decrease in SCA7.