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. 2021 May 26;41(21):4596–4606. doi: 10.1523/JNEUROSCI.2087-20.2021

Figure 2.

Figure 2.

Pain caused by subcutaneous acid is mediated by ASIC1. A, Mice with intact ASIC1 and ASIC2 (ASIC+/+), hemizygous ASIC1 deletion (ASIC1+/−), homozygous ASIC1 deletion (ASIC1−/−), hemizygous ASIC2 deletion (ASIC2+/−), or homozygous ASIC2 deletion (ASIC2−/−) were injected with PBS, pH 5.5, into one hindpaw. The presence (+) or absence (o) of a withdrawal reflex was recorded; n = 5–17 per group, ***p < 0.001, one-way ANOVA with a post hoc Dunnett's test, in which (+) was ranked as 1 and (o) was ranked as 0. B, Mice lacking TrpV1 (TrpV1−/−) were injected with PBS, pH 5.5, or capsaicin (1 µg) into one hindpaw. The presence (+) or absence (o) of a withdrawal reflex was recorded; n = 10 per group, ***p < 0.001, two-tailed Mann–Whitney U test, in which (+) was ranked as 1 and (o) was ranked as 0.