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NAC significantly decreased HIF1-α expression of Th17 and Treg cells isolated from peripheral blood of COPD patients. Inflammation-pathway array, western-blot, and qRT-PCR revealed the decreased expression of HIF1-α in Th17 and Treg cells in the NAC control group. (∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001).
