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. 2021 Jun 7;595(7866):278–282. doi: 10.1038/s41586-021-03676-z

Extended Data Fig. 9. Structural analysis of nanomice and llama nanobody interface with the SARS-CoV-2 spike.

Extended Data Fig. 9

a, Structure of Nb12 and RBD region (inset, interface between Nb12 and RBD with contact resides shown in stick representation). b, Structure of Nb30 and RBD region (inset, interface between Nb30 and RBD with contact resides shown as stick representation). c, Cryo-EM defined structures of nanomouse nanobodies recognize regions on RBD distal from residues 417, 484 and 501 (affected by mutations in emerging variants). d, SARS-CoV-2 spike (HexaPro) structure in two perpendicular views. e, Spike–Nb15 (red) complex structure in two perpendicular views. f, Spike–Nb17 (light green) complex structure in two perpendicular views. g, Spike–Nb19 (dark green) complex structure in two perpendicular views. h, Spike–Nb56 (purple) complex structure in two perpendicular views.