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. 2021 Jun 7;595(7866):278–282. doi: 10.1038/s41586-021-03676-z

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Neutralization using trivalent Nb56 and Nb12, and bivalent Nb30, against pseudoviruses carrying SARS-CoV (left) or bat coronavirus WIV16 (right) spikes. Data are representative of two independent experiments and the error bars are mean ± s.d. of triplicates. b, BLI analysis of trivalent Nb56 and Nb12, and bivalent Nb30, binding to immobilized RBD from SARS-CoV-2 (left), SARS-CoV (middle) and bat coronavirus WIV16 (right). Equilibrium (K_D) constants are provided. c, IC₅₀ (pM) values for neutralization in culture assays, showing the sensitivity of HIV-1 and VSV pseudotyped viruses containing 13 sarbecoviral spike proteins. d, Analysis of bone marrow (top) or splenic (bottom) B cells was done by gating lymphocytes (first plot), avoiding aggregates (plots 2 and 3), B220⁺apoptotic⁻ gaiting (plot 4), and visualization with cell-surface makers as indicated (plots 5 and 6).