Table 2.

Fasting blood levels of glucose and insulin, HOMA-IR, and HOMA-β in males, females, OVX-Veh and OVX-E₂ female mice exposed to normoxia (NX) or intermittent hypoxia (IH)

	Males	Females	OVX-Veh	OVX-E2
Glucose, mM
Nx	10.8 ± 1.4 (n = 10)	7.1 ± 0.7 (n = 9)°°°°	8.3 ± 1.2 (n = 15)°°	7.0 ± 0.7 (n = 10)°°
IH	6.6 ± 1.2**** (n = 10)	7.1 ± 0.8 (n = 11)	7.3 ± 1.1 (n = 13)**	6.0 ± 0.8 (n = 13)*/°°°
Insulin, ng/mL
Nx	2.1 ± 0.3	0.8 ± 0.6°°°°	1.0 ± 0.4	0.6 ± 0.3°
IH	0.8 ± 0.4****	0.6 ± 0.4	0.5 ± 0.3***	1.2 ± 0.4**/°°°°
HOMA-IR, I × G /22.5
Nx	1.00 ± 0.21	0.25 ± 0.17°°°°	0.38 ± 0.20	0.19 ± 0.09°°
IH	0.24 ± 0.13****	0.19 ± 0.15	0.16 ± 0.10***	0.33 ± 0.15*/°°
HOMA-β, I/G
Nx	0.20 ± 0.05	0.11 ± 0.09°°	0.12 ± 0.05	0.09 ± 0.06
IH	0.11 ± 0.06**	0.08 ± 0.06	0.07 ± 0.03*	0.19 ± 0.06***/°°°°

Values are means ± SD. Number of animals within each group indicated as (n = x)

^*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, IH vs. NX.

°P < 0.05, °°P < 0.01, °°°P < 0.001, and °°°°P < 0.0001 vs. precedent column (females vs. males, OVX-Veh vs. females, OVX-E₂ vs. OVX-Veh).