Table 2.
Comparison of vascular density values obtained in brains of young and aged mice with data from the literature
| Age-Related Brain Vascular Rarefaction (Density Decline) | |||
|---|---|---|---|
| Species | Region | Change | Reference |
| Rat | Frontal, occipital cortex | ↓ | (40) |
| Rat | Frontal cortex | ↓ | (41) |
| Rat | Olfactory bulb | ↓ (15%) | (42) |
| Rat | Medial nucleus of the trapezoid body | ↓ (30%) | (43) |
| Rat | Whole brain | ↓ (10–30%) | (44) |
| Rat | CA1, parietal cortex | ↓ | (45,46) |
| Rat | Frontal, occipital cortex, hippocampus | ↓ | (47) |
| Mouse | Parietal cortex | ↓ (15%) | (22) |
| Mouse | Cerebral cortex | ↓ (25%) | (48) |
| Mouse | Parietal cortex | ↓ [18% (OCT), 35% (MP)] | Current study |
Age-related percentile changes in calculated murine cerebral vascular density values derived from the referenced studies and obtained in the current study are shown. MP, two-photon microscopy; OCT, optical coherence tomography.