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. 2021 Jan 22;320(4):H1321–H1336. doi: 10.1152/ajpheart.00435.2020

Figure 2.

Figure 2.

Exposure to inorganic arsenic (iAS) induces sex-dependent hypertrophy of the heart. Left ventricular mass (LV mass) extrapolated from transthoracic echocardiography in females (A) and males (B) (*P = 0.0149 vs. control, two-way ANOVA with Tukey’s multiple comparisons) at 0, 4, and 8 wk of exposure (n = 9-10 mice/group). Heart mass normalized to tibia length (HW/TL) in females (C) and males (D) (****P < 0.0001 vs. control; n = 24-25 hearts/group). Plasma atrial natriuretic peptide (ANP) in females (E) and males (F) (*P = 0.0379 vs. control; n = 9-10 mice/group). Plasma brain natriuretic peptide (BNP) in females (G) and males (H) (n = 9-10 mice/group). Outliers were determined by the ROUT method (Q = 1%), and significance was determined by Mann–Whitney test.