Figure 3.

Losartan treatment ameliorates chronic, inhaled nicotine-induced pulmonary hypertension measured by cardiac catheterization. A: representative right ventricular (RV) pressure tracings for mice exposed to air (upper left), air and losartan (upper right), nicotine (lower left), and nicotine and losartan (lower right). B: RV systolic pressure (RVSP) in air- and nicotine-exposed mice with or without losartan treatment. n = 11–14/group. C: Fulton index in air- and nicotine-exposed mice with or without losartan treatment. n = 13–19/group. D and E: RV weight and left ventricular (LV) and interventricular septum (S) weight. n = 13–19/group. Data are displayed as means ± SE. *P < 0.05, ****P < 0.0001 (two-way ANOVA with Tukey–Kramer post hoc test).