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. 2021 May 21;129(2):326–341. doi: 10.1161/CIRCRESAHA.121.318868

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© 2021 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 7. — CalTrack defines calcium transient changes caused by the TnnI3^R145G/+ hypertrophic cardiomyopathy (HCM) variant in paced (0.5 Hz) adult guinea pig cardiomyocytes. A, Normalized mean calcium transients and calcium decays (B) from wild-type (WT; n=47) or TnnI3^R145G/+ (n=88) guinea pig cardiomyocytes. The TnnI3^R145G/+ variant does not affect peak fluorescence/baseline fluorescence (F_max/F₀; C), and calcium decay constant (Tau; D). Time to 50% of calcium peak (T50_on) is accelerated (E), but time to reach calcium peak (T_on; F), time of 50% calcium decay (T50_off; G), time for calcium transient decay (T_off; H), and calcium transient duration (CD; I) are all slowed in comparison to WT. Data presented as mean and SD. Statistical analysis is performed by a 2-tailed Student t test (T_on, T_off, and CD) or by nonparametric Mann-Whitney test (F_max/F₀, Tau, T50_on, and T50_off) with a significance cutoff of P<0.05. ns indicates nonsignificant. AU indicates arbitrary units.