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. 2021 Jul 7;40:101243. doi: 10.1016/j.nantod.2021.101243

Fig. 7.

Fig. 7

Antiviral evaluation of Ag-TiO2 SAN in vivo. (a-b) Small animal imaging for the lung tissues of hACE2 transgenic mice, which were atomized with or without Ag-TiO2 SAN (10 mg kg−1) for 1 h, then were atomized with Cy5.5 labeled S1 RBD (2 mg per mouse) or SARS-CoV2 pseudovirus (104.5 TCID50). The same control (PBS treated) was used in a and b. (c-d) The statistics of radiant efficiency of S1 RBD (c), and pseudovirus (d) infected lung tissues of hACE2 transgenic mice (n = 3). (e) Ag-TiO2 SAN enhances SARS-CoV2 pseudovirus uptake of mouse macrophages. (f) Ag-TiO2 SAN enhances SARS-CoV2 pseudovirus uptake of human macrophages. (g-h) TEM images show Ag-TiO2 SAN colocalized with lysosomes of mouse and human macrophages. (i-j) Ag-TiO2 SAN enhances ROS generation of macrophages.