Table 3.

Predicted pharmacokinetic properties of 3, 4, and 5 by SwissADME.

Compound	GI absorption	BBB permeant	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	Log Kp (skin permeation) (cm/s)
3	Low	No	No	No	No	No	No	No	− 8.74
4	High	No	No	Yes	No	Yes	No	Yes	− 6.92
5	High	No	No	Yes	No	No	No	No	− 7.36

GI: gastrointestinal; BBB: blood–brain barrier; P-gp: P-glycoprotein; CYP: Cytochrome P450.