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. 2021 Jul 6;11:13912. doi: 10.1038/s41598-021-93113-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association of clinical outcome and expression of antigen-presenting DC-related gene and CXCR3 ligands genes in tumor tissue in the phase 3 OAK trial. (A) Relation between overall response rate and AP/T score. (B) Forest plots of hazard ratios (HR) for OS in the biomarker-evaluable population (BEP) and in subgroups with AP/T scores above the 30th, 50th, and 70th percentile cut-off points (top 70%, 50%, and 30% of the population, respectively). (C, D) Kaplan–Meier estimates and forest plots of HRs for OS in the HIGH and LOW AP/T subgroups (cut at 50th percentile) in the atezolizumab and docetaxel treatment arms.