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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Gut. 2021 Jan 7;70(11):2138–2149. doi: 10.1136/gutjnl-2019-320462

Figure 7.

Figure 7.

The sum of ID2 and ID7 effectively separated CRCs from MMR pathogenic variant carriers (n=17) from the MMRp control CRCs (n=98) at low somatic VAF thresholds (<0.2) (a) and across a broad range of minimum DP thresholds (>25bp) (b) when applied to the CRCs in the discovery set. When applied to the validation set of CRCs, we similarly observe a combined ID2 and ID7 TMS could effectively discriminate CRCs from MMR pathogenic variant carriers from CRCs from the MMRp controls at low VAF thresholds (≤0.1) (c) and across broad range of minimum DP thresholds (d).